Several Open Books

Selected Publications

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2021

  • Elhenawy W, Hordienko S, Gould S, Oberc A, Tsai CN, Hubbard T, Waldor MK, Coombes BK. High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli. Nature Communications. (2021) Apr 1; 12 (1):2032. (Top 50 Editor’s Highlights in Microbiology and Infectious Disease)

  • Chau NYE, Pérez-Morales D, Elhenawy W, Bustamante BH, Zhang YE, Coombes BK. (p)ppGpp-dependent regulation of PpnNST confers complement resistance by Salmonella Typhimurium. Infection & Immunity. (2021) Jan 19;89(2):e00639-20.

2019

  • Elhenawy W, Tsai CN, Coombes BK. Host-specific adaptive diversification of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Host & Microbe. (2019) Feb 13;25(2):301-312.e5. 

  • Ellis M, Tsai CN, Johnson J, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Coombes BK, Brown ED. A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium. Nature Communications. (2019) Jan 14;10(1):197.

  • Shaler CR, Elhenawy W, and Coombes BK. The unique lifestyle of Crohn’s disease-associated adherent invasive Escherichia coli. Journal of Molecular Biology. (2019) Apr 25; pii: S0022-2836(19)30230-X. 

  • Ladinsky, MS, Araujo LP, Zhang X, Lee C, Veltri J, Galan-Diez M, Soualhi S, Irie K, Pinker E, Narushima S, Bandyopadhyay S, Nagayama M, Elhenawy W, Coombes BK, Ferraris RP, Honda K, Iliev ID, Gao N, Bjorkman PJ, Ivanov II. Directed endocytosis mediates immune communication between an epithelial commensal microbe and the host. Science. (2019) Mar 8;363(6431). pii: eaat4042.

  • Oberc A, Fiebig-Comyn AA, Tsai CN, Elhenawy W, Coombes BK. Antibiotics potentiate adherent-invasive E. coli infection and expansion. Inflammatory Bowel Diseases. (2019) Mar 14;25(4):711-721.

2018

  • Ilyas B, Mulder DT, Little DJ, Elhenawy W, Banda M, Perez-Morales D, Tsai CN, Chau NYE, Bustamante VH, Coombes BK. Regulatory evolution drives evasion of host inflammasomes by  Salmonella Typhimurium. Cell Reports. (2018) Oct 23;25(4):825-832.e5.

  • Elhenawy W, Oberc A, Coombes BK. A polymicrobial view of disease potential in Crohn's associated adherent-invasive E. coli. Gut Microbes. (2018) Mar 4;9(2):166-174.